Compound Management

We have extensive offerings in compound management and logistics and have been helping clients off load these time intensive tasks for years. We can store, keep track of inventory,  label,  package (or repackage) and ship  research compounds so you do not have to!

Our compound management process uses  an established protocol to receive,  store, ship and track compounds in a safe and secure environment  Let us customize a solution for your program.

Storage and Logistics

It can be difficult and time consuming to manage a compound inventory, even more so without internal chemistry resources. We  provide custom solutions to our clients’ inventory and logistics needs. Consolidating all compounds in one location helps eliminate lost compounds or duplication of effort.

        Compound storage

  • Refrigeration (4° C, -20°C)
  • Low Temperature ( -80°C)
  • Inert atmosphere
  • Small molecule
  • Peptides, proteins antibodies

Material sampling and shipping

  • Sampling, labeling
  • Packing, re-packing
  • MSDS or COA generation
  • Shipping and logistics
  • Inventory maintenance

Compound Profiling

  • Chemical Purity
  • Solubility
  • Compound stability
  • Formulation
  • LogC and LogD
  • Contaminate Profiles
  • Formulation Stability
  • Salt Selection
  • pH profiles
  • Shelf life

Compound Profiling: Knowing how your compound will react  under different conditions is key to developing a robust candidate. We can help identify the physicochemical properties of your compound early on to ensure proper testing and handling.  We can profile your compounds and formulations to assure quality and reliability.

Certificate of Analysis preparation: Certification and re-certification of research compounds is critical to assure batch to batch reproducibility. We have a variety of testing methods available and can customize the right COA for the project.

Pre-Formulation

Discovery Pre-formulation:   Having trouble  getting  your  compound  in solution?  Many  small  molecules s  show  poor solubility and full-blown formulation studies can be expensive. We have years of experience designing formulation strategies for  in  vivo  work to overcome solubility and stability issues.  Let us find the right formulation for you.

    • Co-solvents
    • Excipients
    • pH control
  • Salt switching
  • Lipid formulations
  • Hydrogels

Pro-drugs:   Some compounds are quite difficult to formulate! For truly problematic compounds, we can prepare pro-drugs to help with solubility or stability issues.  We can design the pro-drug to be highly stable, or to liberate the drug under very controlled conditions.  Let us design the perfect pro-drug for your application.

Analytical services

We have a variety of analytical tools both in house and available through our collaborators. We routinely perform LC/MS, NMR and other analytical tests to assure purity, determine or confirm structure, or to benchmark material. We can customize a data package to give confidence in the quality, purity and identity of compounds with turnaround times of as little as 24h depending on the assay.

  • HPLC (normal phase, reverse phase, chiral)
  • LC/MS (uv and ELDS detection)
  • UV/vis
  • 1H, 13C, 31P 19F 1D and 2D NMR
  • Access to IR, MALDI, KF, Elemental, DLS,
  • zeta potential, ion chromatography, and many more

© 2017 MedChem Partners      I       99 Hayden Ave., Suite 210 Lexington, MA 02421       I       Tel (781) 676-2000       I    email us